It is appropriate to investigate the potential analogies between architecture and biology enabled by the use of digital processes, thereby testing the effectiveness of the application of biological principles to the lifecycle of buildings. The aim of this paper is to understand the way architects integrate and develop different biological approaches to architecture, by mapping the present situation and identifying the trends for future developments. Three major approaches were identified: biomimetics, bionics and biotechnology. The use of biological knowledge and technology in architecture, could pave the way for solutions to current problems, such as energy shortage, climate change, and lifestyle diversity.