Several building works have demonstrated the possibilities of architectural design based on structural performance. This work discusses some examples and digital design strategies that approach this issue, as well as an exercise for a tower generated through topological optimization. That experience presents alternatives for a traditional office tower in Santiago, Chile, the Torre Santa Maria, based on generative design strategies for the incorporation of structural and environmental requirements to define parametric models. The experience and the capabilities studied reveal an intensive variation of architectural shape. This approach challenges conventional building regularity and suggests new ways of designing based on material performance.