As part of an ongoing research project, this Paper is intended to present some of the main questions emerged when preparing a series of experiments for the generation and arrangement of facade elements in mass customized dwellings. In general, two differing approaches have been tried in panelization of regular and irregular facades in buildings. The first one is based on dimensional coordination strategies and is regarded as being the most efficient in terms of material usage and production rationalization. The other is derived from the more open strategy of deriving individual panel dimensions from a UV grid and its transformations.