This paper assumes the façade as an innovative element of interaction between the inside and the outside: the architectural skin. As in nature, one of its most significant functions is the energy exchange with the environment. Similarly, efficiency increases by passive and active responses to climate conditions and site orientation. This research explores the potential of parametric techniques, programming and digital manufacturing, to design and build a Bioclimatic Responsive Skin (BRS). Firstly, we designed a bio-component applicable to any surface due to its parametric nature. Secondly, we fabricated two non-reactive working prototypes to study the manufacturing and construction details. Thirdly, we integrated the physical and the digital interfaces by using Generative Components™, Arduino, and Ubimash to generate a kinetic responsive model. This prototype was presented at SmartGeometry Workshop and Conference 2010. Finally, Lem3a architecture used this BRS in a real design project for a Sustainable house in New Hope, PA.