In this paper we explore the land-use patterns of a historical mixed-use quarter of Istanbul by focusing on the reciprocal relationships of housing and commercial uses. We are concerned with the distribution of land-use patterns based on spatial adjacency and land-use patterns within the buildings. We measure reciprocal relationships of housing and commercial uses by using GIS and Data Mining in a complementary way and we test if we can re-generate these relationships by evolutionary computation to further support land-use allocation in inner city regenerations or new urban developments.