The paper argues that the tower needs to respond to its environment by changing from a closed building typology towards a heterogeneous, differentiated open system that can adapt to the changing conditions within and around it. This argument is supported by focusing on the analogies and principles of specific biological examples in order to propose computationally-generated self-organizing systems. The goal of analyzing these models is to integrate their structural and geometrical characteristics with the aim of overcoming high lateral loading conditions in towers, as well as elaborating on the existence of multi-functionality and integration throughout the subsystems of the tower. A series of computational models which abstract the biological properties and articulate them with a generative approach through the use of agent-based systems are implemented according to designated evaluation criteria.