The awareness of the environmental impact of buildings concerning their CO2 emissions, their energy and resource consumption has raised the challenges on building design, construction and operation. Building service systems are among the main contributors to building related emissions. Their consideration already in design is therefore of growing importance. Distributed service systems represent a new paradigm towards the supply of a building with energy and matter. Being small, efficient and networked, they can be distributed within the building fabric to allow an efficiently supply of the building space. Their employment, however, affects the spatial layout, construction and resulting building performance. In order to capture the resulting complex dependencies, a strategy to integrate such systems into the architectural design process is necessary. In this work a design process is proposed, that integrates distributed service systems into building design, dissolving the classical divide between architectural design and service systems layout. Digital modelling and computational methods are employed to create and analyse design solutions, visualize performance criteria and provide the relevant data for the intended digital fabrication process. The process is exemplified using a joint university-industry case study project focusing on parametric façade modules, developed in a seamless digital process from concept to fabrication.