This research attempts to integrate a new technology-Multi- Display Environment (MDE)-into the design and creation of new architectural spaces-multi-display spaces. The research objective is to formulate a set of design guidelines that advise designers on the effective use of the MDE technology, so that the technology may become a new design element and enables designers to show amplification effects of spaces. Two empirical studies are conducted. Based on the results of empirical studies, a set of multi-display space design guidelines is formulated with three key aspects: scene selection, display allocation and display arrangement. The design guidelines require further validations through practical applications. Nevertheless, the research introduces a new design element for designers to think about the future of architectural spaces with more opportunities and possibilities.